背景:直肠鳞状细胞癌(rSCC)的治疗策略尚未建立,鉴于它的稀有性。尽管据报道鳞状细胞癌对西妥昔单抗和放射线高度敏感,尚无西妥昔单抗联合放疗治疗rSCC的报道.在这项研究中,我们首先报道了一例rSCC,其中最初的放化疗包括奥沙利铂,S-1西妥昔单抗,同时辐射。
方法:一名46岁妇女因下腹痛和疲劳就诊。
方法:基于肿瘤标志物分析,活检标本的组织学检查,和综合成像,患者被诊断为rSCC.
方法:新辅助放化疗(50.4Gy)分28次进行,同时化疗包括SOX(S-1:80mg/m2,第1-5天和第8-12天,奥沙利铂:85mg/m2,第1天)和西妥昔单抗(400mg/m2,第1天,250mg/m2,第8天之后)。
结果:放化疗后五周,患者接受了腹腔镜部分括约肌间切除术,实现完整的病理反应。
结论:该病例首先强调了SOX联合西妥昔单抗联合放疗治疗局部晚期rSCC的有效性。然而,需要进行大规模研究以建立安全有效的治疗方案.
BACKGROUND: Treatment strategies for rectal squamous cell carcinoma (rSCC) are yet to be established, given its rarity. Although squamous cell carcinoma has been reported to be highly sensitive to cetuximab and radiation, there is no report of combination therapy of cetuximab and radiation for rSCC. In this study, we firstly reported a case of rSCC in which a complete response was achieved with the original chemoradiotherapy comprising oxaliplatin, S-1, cetuximab, and simultaneous radiation.
METHODS: A 46-year-old women presented to our hospital with lower abdominal pain and fatigue.
METHODS: Based on tumor marker analyses, histological examination of biopsy specimens, and comprehensive imaging, the patient was diagnosed with rSCC.
METHODS: Neoadjuvant chemoradiotherapy (50.4 Gy) was administered in 28 fractions, along with concurrent chemotherapy comprising SOX (S-1: 80 mg/m2, days 1-5 and 8-12, oxaliplatin: 85 mg/m2, day 1) and cetuximab (400 mg/m2, day 1, 250 mg/m2, after day 8).
RESULTS: Five weeks after chemoradiation, the patient underwent laparoscopic partial intersphincteric resection, achieving a complete pathological response.
CONCLUSIONS: This case firstly highlights the usefulness of SOX plus cetuximab combined with radiation in the treatment of locally advanced rSCC. However, a large-scale study is required to establish safe and effective treatment regimens.